DLCO: adjust for lung volume, standardised reporting and interpretation

نویسندگان

  • Brian L. Graham
  • Vito Brusasco
  • Felip Burgos
  • Brendan G. Cooper
  • Robert Jensen
  • Adrian Kendrick
  • Neil R. MacIntyre
  • Bruce R. Thompson
  • Jack Wanger
چکیده

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DLCO: adjust for lung volume, standardised reporting and interpretation

The American Thoracic Society (ATS) and European Respiratory Society (ERS) should be congratulated on updating standards for diffusing capacity of the lung for carbon monoxide (DLCO) [1]. I agree that “Besides varying with age, sex, height and possible ethnicity, DLCO also changes with Hb, lung volume, COHb, PIO2 ..., exercise and body position.” and that “adjustments for these factors be made ...

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BACKGROUND In healthy volunteers, the single-breath diffusing capacity of the lung for carbon monoxide (DLCO) decreases and DLCO normalized per liter alveolar volume (VA; DLCO/VA) increases if VA is decreased. We hypothesized that comparison of DLCO/VA with its predicted value at predicted total lung capacity (TLC) will result in an underestimation of the diffusion disorder in patients with a r...

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Are there sex differences in the capillary blood volume and diffusing capacity response to exercise?

Previous work suggests that women may exhibit a greater respiratory limitation in exercise compared with height-matched men. Diffusion capacity (DlCO) increases with incremental exercise, and the smaller lungs of women may limit membrane diffusing capacity (Dm) and pulmonary capillary blood volume (Vc) in response to the increased oxygen demand. We hypothesized that women would have lower DlCO,...

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Lung diffusing capacity (DL) for carbon monoxide (DLCO), nitric oxide (DLNO) or oxygen (DLO2) increases from rest to peak exercise without reaching an upper limit; this recruitment results from interactions among alveolar volume (VA), and cardiac output (q), as well as changing physical properties and spatial distribution of capillary erythrocytes, and is critical for maintaining a normal arter...

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عنوان ژورنال:

دوره 50  شماره 

صفحات  -

تاریخ انتشار 2017